New Clinical Study Validates Dynamic Pupillary Responses as Functional Biomarkers for Age-Related Macular Degeneration (AMD)
Bulbitech Announces the Publication of a New Peer-reviewed Clinical Study Validating Dynamic Pupillary Responses as Objective Biomarkers for Age-related Macular Degeneration (AMD), Supporting Earlier Detection and Improved Disease Monitoring.
Bulbitech is proud to share the publication of “Dynamic Pupillary Responses in Age-Related Macular Degeneration: A Controlled Clinical Study Using High-Frequency Video-Oculography.” The study provides clinical evidence that dynamic pupillary response measurements can serve as reliable functional biomarkers in patients with AMD.
The research was led by our Innovation Manager Bjørn André Helland-Hansen, supervised by Professor Goran Petrovski at the Center for Eye Research and Innovative Diagnostics, and co-authored by Alexander Sverstad.
Addressing the Global Challenge of Age-Related Macular Degeneration
AMD is one of the leading causes of vision loss worldwide, particularly among individuals over the age of 50. As populations age, the prevalence of AMD continues to rise, increasing the demand for earlier diagnosis, objective disease monitoring, and innovative ophthalmic technologies.
Traditional diagnostic approaches primarily rely on structural imaging and subjective assessments. However, there is a growing need for objective, functional biomarkers that can detect subtle physiological changes before significant vision loss occurs.
High-Frequency Video-Oculography for Early AMD Detection
The study demonstrates that high-frequency video-oculography can detect measurable alterations in dynamic pupillary responses in patients with AMD. These findings validate pupillary response metrics as functional indicators of retinal dysfunction.
Key benefits of this approach include:
Non-invasive assessment
Objective and quantifiable measurements
Potential for early-stage AMD detection
Improved monitoring of disease progression
Scalable clinical application
By establishing dynamic pupillary responses as clinically relevant biomarkers, this research supports the development of more precise and accessible AMD diagnostic tools.
Advancing Functional Biomarkers in Ophthalmology
Functional biomarkers play a critical role in modern ophthalmology, particularly in chronic retinal diseases such as AMD. Objective measurement of physiological responses can enhance screening programs, guide treatment decisions, and support clinical research.
This publication marks an important step toward integrating pupillary response analysis into broader AMD management strategies.
Bulbitech’s Commitment to Early Detection of AMD
At Bulbitech, we are dedicated to advancing non-invasive ophthalmic technology that enables earlier detection and better monitoring of retinal diseases. Our mission is to develop clinically validated solutions that improve patient outcomes through objective functional biomarkers.
Read the Full Publication:
Dynamic Pupillary Responses in Age-Related Macular Degeneration: A Controlled Clinical Study Using High-Frequency Video-Oculography.